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THURSDAY, May 8, 2025 (HealthDay News) — A new drug combo lowers "bad" LDL cholesterol for people whose levels remain high even after taking statins.

The new pill pairs a new drug called obicetrapib with an existing one, . In a Phase 3 clinical trial, this combo reduced LDL levels by nearly 49% over about three months, according to Cleveland Clinic researchers. 

The results were presented Wednesday at the European Atherosclerosis Society meeting in Glasgow, Scotland, and simultaneously published in .

“High LDL is one of the leading risk factors for heart disease, and we have such a poor handle on controlling that risk,� , a cardiologist at Columbia University, told NBC News. “Many people have such a high LDL they will require multiple agents to control it.� 

The trial included 407 people with an average age of 68. Even though they were taking cholesterol-lowering medications, everyone had LDL levels above 70 mg/dL. Researchers divided participants into four groups: One took the combo pill; two groups took each drug separately; and another group took a placebo. All participants continued their usual cholesterol medications.

, a preventive cardiologist at the Cleveland Clinic, led the study.

“We need to give patients and their doctors all the options we can to try to get LDL under control if they are at risk for, or already have, cardiovascular disease,� Sarraju said. “In higher-risk patients, you want to get LDL down as quickly as possible and keep it there as long as possible.� 

High-risk patients are those who have had a stroke or heart attack, or are likely to have one. Even high-intensity statins are sometimes not enough to bring LDL to safe levels. 

The (AHA) recommends keeping LDL below 100 mg/dL — and under 70 mg/dL for high-risk patients.

The trial was funded by NewAmsterdam Pharma, the Dutch company that makes obicetrapib. The company plans to speak with the U.S. Food and Drug Administration (FDA) “over the course of the year,� about possible approval of the combo drug, a spokesperson told NBC News.

In the past, some similar drugs have not worked. of Mount Sinai Health System noted that some drugs in this class have failed to prevent or . “But I am cautiously hopeful,� he said.

NewAmsterdam Pharma is now running another trial to see if the combo drug not only lowers cholesterol but also protects against major heart events.

While lifestyle changes like eating healthy, exercising and avoiding smoking can help lower LDL, many people still struggle to reach safe levels. Only about 20% of patients are able to manage their LDL, said Bradley, of Columbia.

More information

The Mayo Clinic has more on .

SOURCE: NBC News, May 7, 2025

What This Means For You

If you have high LDL despite taking statins, this new drug combo may offer another way to lower your risk of heart problems.